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ESHRE PGD Consortium data collection VIII: cycles from January to December 2005 with pregnancy follow-up to October 2006

机译:ESHRE PGD协会数据收集八:从2005年1月至12月的周期,以及妊娠随访至2006年10月

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摘要

The eighth report of the European Society of Human Reproduction and Embryology PGD Consortium is presented documenting cycles collected for the calendar year 2005 and follow-up of the pregnancies and babies born until October 2006 which resulted from these cycles. For the first time, the delivery rates for each indication are presented and also the pregnancy rates for each centre are reported anonymously. Since the first data collections, there has been a steady increase in the number of cycles, pregnancies and babies reported annually. For data collection VIII, 39 centres have participated, reporting on 3488 cycles to oocyte retrieval (OR), along with details of the follow-up on 845 pregnancies and 670 babies born. Five hundred and twenty OR were reported for chromosomal abnormalities, 108 OR for sexing for X-linked diseases, 500 OR for monogenic diseases, 2275 OR for preimplantation genetic screening and 85 OR for social sexing. Data VIII is compared with the cumulative data for data collections I–VII.
机译:欧洲人类生殖与胚胎学学会PGD协会的第八份报告介绍了记录在2005日历年的周期以及由于这些周期而导致的直到2006年10月的孕妇和婴儿的随访情况。首次显示每个适应症的分娩率,并匿名报告每个中心的怀孕率。自从首次收集数据以来,每年报告的周期,怀孕和婴儿数量一直在稳定增长。对于第八次数据收集,有39个中心参与,报告了3488个卵母细胞取回(OR)周期,并报告了845例妊娠和670例婴儿的随访情况。据报道,染色体异常有520个OR,与X连锁疾病有关的性别鉴定为108 OR,单基因疾病为500 OR,植入前基因筛查为2275 OR和社会性别为85 OR。将数据VIII与数据收集I–VII的累积数据进行比较。

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  • 来源
    《Human Reproduction》 |2008年第12期|2629-2645|共17页
  • 作者单位

    ESHRE Central Office Meerstraat 60 1852 Grimbergen Belgium;

    Genetics and IVF Institute 3015 Williams Drive Fairfax VA 22031 USA;

    Service de la Biologie de la Reproduction SIHCUS-CMCO 19 Rue Louis Pasteur BP120 67303 Schiltigheim France;

    Cytogenetics Department and Centre for Preimplantation Genetic Diagnosis Guy’s and St Thomas’ NHS Foundation Trust Guy’s Hospital Great Maze Pond London SE1 9RT UK;

    Laboratory of Medical Genetics University of Athens St Sophia’s Children’s Hospital 11527 Athens Greece;

    Department of Embryology and Genetics of the VUB and Centre for Medical Genetics of The Universitair Ziekenhuis Brussel Laarbeeklaan 101 1090 Brussels Belgium;

    UCL Centre for PGD Institute for Women’s Health University College London 86-96 Chenies Mews WC1E6HX London UK;

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