Quantitative EEG in Prediction of Efficiency of Combined Antidepressive Treatment Using Transcranial Magnetic Stimulation

摘要

In order to search for possible EEG predictors of the effectiveness of combined antidepressive therapy, which includes a three-week course of high-frequency rhythmic transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) of the left hemisphere in 30 patients with drug-resistant depression the correlations between pre-treatment EEG spectral power values, and post-treatment quantitative outcome conditions of patients were analyzed. The “responders” (23 out of 30) exhibited significant negative correlations of the post-treatment HDRS-17 scale total score with the EEG spectral power values in θ2 (6–8 Hz) and α1 (8–9 Hz) frequency sub-bands in the parietal–occipital–posterior temporal leads. The “non-responders” (7 out of 30) exhibited similar correlations between the post-treatment HDRS-17 scale total score and θ2 (6–8 Hz) EEG sub-band spectral power in the frontal–central–temporal areas of the right hemisphere. Thus, possible EEG predictors of the effectiveness of combined antidepressive therapy, including rTMS of the left DLPFC, are the pre-treatment parameters of θ2 and α1 EEG frequency sub-bands.