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Health Risk Assessment and Vapor Intrusion: A Review and Australian Perspective

机译:健康风险评估和蒸气入侵:回顾与澳大利亚观点

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摘要

Soil contamination by volatile hydrocarbons is of public health importance due to vapor intrusion and indoor inhalation exposures. These are assessed using measurement or predictive modeling and need to consider the key areas of subsurface partitioning and transport, dwelling ventilation, and receptor inhalation dosimetry. While subsurface partitioning and transport have been subject to intensive international investigation, limited consideration has been given to the latter. Building ventilation research has developed multi-zone airflow and contaminant dispersal models including AccuRate, an Australian model that examines natural ventilation modeling, roof and sub-floor ventilation, and identifies the importance of geometry and thermal factors on ventilation (the most sensitive variable) and indoor pollutant concentrations. Inhalation dosimetry has received recent attention due to concerns over child inhalation susceptibility and dose metrics. Research using coupled computational fluid dynamics (CFD) and physiologically based pharmaco-kinetic (PBPK) models has reported variance from previous animal models' extrapolation while CFD modeling of transient lung vapor absorption suggests the significance of transient versus steady-state evaluation of volatiles absorption into tissue and blood. The transient nature of sub-surface fate and transport, ventilation, and inhalation uptake thus warrants integrated exploration and application in order to realize improvements in vapor intrusion assessments. These perspectives and Australian modeling initiatives are presented in this article.
机译:由于蒸气入侵和室内吸入暴露,挥发性碳氢化合物对土壤的污染对公共健康至关重要。这些使用测量或预测模型进行评估,需要考虑地下分区和运输,居住通风和受体吸入剂量的关键领域。尽管地下分区和运输受到了广泛的国际调查,但对后者的考虑却有限。建筑通风研究已开发了多区域气流和污染物扩散模型,包括澳大利亚的AccuRate模型,该模型检查自然通风模型,屋顶和底层地板的通风情况,并确定几何形状和热因素对通风的重要性(最敏感的变量),以及室内污染物浓度。由于对儿童吸入敏感性和剂量指标的担忧,吸入剂量测定法最近受到关注。使用耦合计算流体动力学(CFD)和基于生理学的药代动力学(PBPK)模型进行的研究报告了先前动物模型的推断差异,而瞬态肺蒸气吸收的CFD模型表明,对挥发性吸收进入瞬态与稳态评估的重要性组织和血液。因此,地下命运以及运输,通风和吸入吸收的瞬态性质保证了综合的勘探和应用,以实现对蒸汽入侵评估的改进。本文介绍了这些观点和澳大利亚建模倡议。

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