Antiviral activity, dose–response relationship, and safety of entecavir following 24-week oral dosing in nucleoside-naive Japanese adult patients with chronic hepatitis B: a randomized, double-blind, phase II clinical trial

Michiko Shindo; Kazuaki Chayama; Satoshi Mochida; Joji Toyota; Eiichi Tomita; Hiromitsu Kumada; Osamu Yokosuka; Michio Sata; Norio Hayashi; Kazuyuki Suzuki; Takeshi Okanoue; Hirohito Tsubouchi; Hiroki Ishikawa; Taku Seriu; Masao Omata

首页> 外文期刊>Hepatology International >Antiviral activity, dose–response relationship, and safety of entecavir following 24-week oral dosing in nucleoside-naive Japanese adult patients with chronic hepatitis B: a randomized, double-blind, phase II clinical trial

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Antiviral activity, dose–response relationship, and safety of entecavir following 24-week oral dosing in nucleoside-naive Japanese adult patients with chronic hepatitis B: a randomized, double-blind, phase II clinical trial

机译：在未经核苷治疗的日本成人慢性乙型肝炎患者中，口服恩替卡韦24周口服给药后的抗病毒活性，剂量反应关系和安全性：一项随机，双盲，II期临床试验

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摘要

A randomized, double-blind, multicenter study (ETV-047) was conducted to evaluate the dose–response relationship of entecavir and compare its antiviral activity and safety with lamivudine in Japanese patients with chronic hepatitis B (CHB).

机译：进行了一项随机，双盲，多中心研究（ETV-047），以评估恩替卡韦在日本慢性乙型肝炎（CHB）患者中的剂量反应关系，并将其抗病毒活性和安全性与拉米夫定进行比较。

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来源
《Hepatology International》 |2009年第3期|445-452|共8页
作者
Michiko Shindo; Kazuaki Chayama; Satoshi Mochida; Joji Toyota; Eiichi Tomita; Hiromitsu Kumada; Osamu Yokosuka; Michio Sata; Norio Hayashi; Kazuyuki Suzuki; Takeshi Okanoue; Hirohito Tsubouchi; Hiroki Ishikawa; Taku Seriu; Masao Omata;
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作者单位

Division of Liver Disease Department of Internal Medicine Akashi Municipal Hospital 1-33 Takasyo-machi Akashi-shi Hyogo Japan;

Department of Medicine and Molecular Science Graduate School of Biomedical Sciences Hiroshima University Hiroshima Japan;

Department of Gastroenterology and Hepatology Saitama Medical University Saitama Japan;

Department of Hepatology Sapporo Kosei General Hospital Hokkaido Japan;

Department of Gastroenterology Gifu Municipal Hospital Gifu Japan;

Department of Hepatology Toranomon Hospital Tokyo Japan;

Department of Medicine and Clinical Oncology Graduate School of Medicine Chiba University Chiba Japan;

Department of Gastroenterology Kurume University School of Medicine Fukuoka Japan;

Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine Osaka Japan;

Department of Internal Medicine Iwate Medical University Iwate Japan;

Department of Gastroenterology Saiseikai Suita Hospital Osaka Japan;

Department of Digestive Disease and Lifestyle-Related Disease Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan;

Pharmaceutical Research Institute Bristol-Myers Squibb Japan Tokyo Japan;

Pharmaceutical Research Institute Bristol-Myers Squibb Japan Tokyo Japan;

Department of Gastroenterology Graduate School of Medicine University of Tokyo Tokyo Japan;

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原文格式 PDF
正文语种 eng
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关键词
Chronic hepatitis B; Entecavir; Lamivudine; HBV DNA; ALT flare;

机译：慢性乙型肝炎;恩替卡韦;拉米夫定;HBV DNA;ALT爆发;

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1. Antiviral activity, dose–response relationship, and safety of entecavir following 24-week oral dosing in nucleoside-naive Japanese adult patients with chronic hepatitis B: a randomized, double-blind, phase II clinical trial [J] . Michiko Shindo, Kazuaki Chayama, Satoshi Mochida, Hepatology international . 2009,第3期

机译：在未经核苷治疗的日本成人慢性乙型肝炎患者中，口服恩替卡韦24周口服给药后的抗病毒活性，剂量反应关系和安全性：一项随机，双盲，II期临床试验
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6. Antiviral activity dose–response relationship and safety of entecavir following 24-week oral dosing in nucleoside-naive Japanese adult patients with chronic hepatitis B: a randomized double-blind phase II clinical trial [O] . Michiko Shindo, Kazuaki Chayama, Satoshi Mochida, 2009

机译：在未经核苷治疗的日本成人慢性乙型肝炎患者中口服恩替卡韦24周口服给药后的抗病毒活性剂量反应关系和安全性：一项随机双盲II期临床试验
7. Antiviral activity, dose–response relationship, and safety of entecavir following 24-week oral dosing in nucleoside-naive Japanese adult patients with chronic hepatitis B: a randomized, double-blind, phase II clinical trial [O] . Shindo, Michiko, Chayama, Kazuaki, Mochida, Satoshi, 2009

机译：在未经核苷治疗的日本成人慢性乙型肝炎患者中，口服恩替卡韦24周口服给药后的抗病毒活性，剂量反应关系和安全性：一项随机，双盲，II期临床试验

Antiviral activity, dose–response relationship, and safety of entecavir following 24-week oral dosing in nucleoside-naive Japanese adult patients with chronic hepatitis B: a randomized, double-blind, phase II clinical trial

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