Peptide YY Administration Decreases Brain Aluminum in the Ts65Dn Down Syndrome Mouse Model

摘要

We have previously reported the Ts65Dn (Ts) mouse has impaired intestinal absorp- Tive function and amino acid metabolism. Peptide YY (PYY) has enhanced glucose absorption in mice And turkeys. Other studies have reported that per- Sons with Down syndrome have increased ntestinal Absorption of aluminum. Alzheimer's - like lesions Have been reported in Ts mice. Trial 1 of this study Examined brain Al concentrations, plasma metabo- Lites and intestinal metabolism of 40 control and 40 Ts mice administered 300μg PYY/kg body weight or 0.9/100 saline for 3d.