INVESTIGATION OF THE EFFECTS OF GASTROESOPHAGEAL REFLUX DISEASE AND SOME PROTON PUMP INHIBITORS ON ERYTHROCYTE ANTIOXIDANT ENZYMES

摘要

In this study, the in vivo effects of two proton pump inhibitors - rabeprazole and esomeprazole - on enzyme activities of red blood cell enzymes, including glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydro-genase, and glutathione reductase, were investigated. In the first part of our study, activities of these enzymes in the group of patients diagnosed with reflux were compared with the enzyme activities of the voluntary individual group with no health problems (control group). No significant difference was found between the groups for glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase enzymes (p ＞ 0.05). However, the level of glutathione reductase increased in reflux patients, as compared to healthy controls (p ＜ 0.05). Additionally, the enzyme activities of the patient group members who used esomeprazole or rabeprazole for a 1 -month-treatment were compared with the values obtained when these patients initially consulted our clinic. No significant difference was found between the groups for the three enzymes (p＞0.05).