Anabolic Effect of Wasabi Leaf stalk (Whsabia japnica MATSUM.) Extract on Bone Metabolism in Rats

摘要

The effect of wasabi leaf stalk (Whsabia japnica MATSUM.) extract on bone metabolism in vivo was investigated. The extract was obtained from a homogenate with 20/100 ethanol and was orally administered 7 times at Wh intervals (l.0, l0, and 40 mg/l00 g body weight) to young rats. Administration of wasabi extract (I.0 and l0 mg/100 g) caused a significant increase in alkaline phosphatase activity, deoxyribonucleic acid (DNA) and calcium contents in the femoral-metaphyseal tissues; the DNA content was significantly elevated by the dose of 40 mg/l00 g. In the femoral-diaphyseal tissues, alkaline phosphatase activity and calcium content were significantly increased by the administration of l.0 and l0 mg/100 g, while the DNA content was not appreciably altered. The present study demonstrates that wasabi leaf stalk extract has an anabolic effcct on bone metabolism in rats in vivo.