Possible Role of Peripheral CD14~low Monocytes in the Development of Collage-Induced Arthritis in Cynomolgus Monkeys(Macaca fascicularis)

摘要

The changes in levels of peripheral major lymphocyte stubsets were monitored with 10 adult conomolgus monkeys(5 females and 5 males)during the 9 weeks after immunization with chick type-II collagen in Freund's complete adjuvant. Three females and 3 males developed overt arthritis determined by swelling of small joints and increase of plasma alkaline phosphatase as well as C-reactive protein.