Synthesis and initial evaluation of [11C](R)-RWAY in monkey—a new, simply labeled antagonist radioligand for imaging brain 5-HT1A</sub> receptors with PET

Julie A. McCarron; Sami S. Zoghbi; H. Umesha Shetty; Eric S. Vermeulen; H?kan V. Wikstr?m; Masanori Ichise; Fumihiko Yasuno; Christer Halldin; Robert B. Innis; Victor W. Pike

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Synthesis and initial evaluation of [11C](R)-RWAY in monkey—a new, simply labeled antagonist radioligand for imaging brain 5-HT1A receptors with PET

机译：[11 C]（R）-RWAY在猴中的合成和初步评估-一种新型的，简单标记的拮抗剂放射性配体，用于用PET成像脑5-HT1A 受体

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摘要

We aimed to fulfill a need for a radioligand that may be simply labeled with carbon-11 for effective positron emission tomography (PET) imaging of brain 5-HT1A receptors.

机译：我们旨在满足对放射性配体的需求，该放射性配体可以简单地用碳11标记，以对脑5-HT1A 受体进行有效的正电子发射断层扫描（PET）成像。

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来源
《European Journal of Nuclear Medicine and Molecular Imaging》 |2007年第10期|1670-1682|共13页
作者
Julie A. McCarron; Sami S. Zoghbi; H. Umesha Shetty; Eric S. Vermeulen; H?kan V. Wikstr?m; Masanori Ichise; Fumihiko Yasuno; Christer Halldin; Robert B. Innis; Victor W. Pike;
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作者单位

Molecular Imaging Branch National Institute of Mental Health National Institutes of Health Building 10 B3 C346A 10 Center Drive Bethesda MD 20892 USA;

Molecular Imaging Branch National Institute of Mental Health National Institutes of Health Building 10 B3 C346A 10 Center Drive Bethesda MD 20892 USA;

Molecular Imaging Branch National Institute of Mental Health National Institutes of Health Building 10 B3 C346A 10 Center Drive Bethesda MD 20892 USA;

Department of Medicinal Chemistry University Center for Pharmacy University of Groningen Groningen The Netherlands;

Department of Medicinal Chemistry University Center for Pharmacy University of Groningen Groningen The Netherlands;

Molecular Imaging Branch National Institute of Mental Health National Institutes of Health Building 10 B3 C346A 10 Center Drive Bethesda MD 20892 USA;

Molecular Imaging Branch National Institute of Mental Health National Institutes of Health Building 10 B3 C346A 10 Center Drive Bethesda MD 20892 USA;

Department of Clinical Neuroscience Psychiatry Section Karolinska Institutet Stockholm Sweden;

Molecular Imaging Branch National Institute of Mental Health National Institutes of Health Building 10 B3 C346A 10 Center Drive Bethesda MD 20892 USA;

Molecular Imaging Branch National Institute of Mental Health National Institutes of Health Building 10 B3 C346A 10 Center Drive Bethesda MD 20892 USA;

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原文格式 PDF
正文语种 eng
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关键词
5-HT1A receptor; PET; Radioligand; 11C(R)-RWAY; Imaging;

机译：5-HT1A受体;PET;放射配体;[11C]（R）-RWAY;成像;

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专利

1. New halogenated (11C)WAY analogues, (11C)6FPWAY and (11C)6BPWAY--radiosynthesis and assessment as radioligands for the study of brain 5-HT1A receptors in living monkey. [J] . Sandell J, Halldin C, Pike VW, Nuclear Medicine and Biology . 2001,第2期

机译：新的卤化（11C）WAY类似物（11C）6FPWAY和（11C）6BPWAY-放射性合成和评估作为放射性配体，用于研究活猴中的脑5-HT1A受体。
2. Evaluation of [11C]S14506 and [18F]S14506 in Rat and Monkey as Agonist PET Radioligands for Brain 5-HT1A Receptors [J] . Current radiopharmaceuticals . 2010,第1期

机译：[11C] S14506和[18F] S14506在大鼠和猴子中作为脑5-HT1A受体激动剂PET放射性配体的评估
3. Synthesis of a (6-pyridinyl-18F)-labelled fluoro derivative of WAY-100635 as a candidate radioligand for brain 5-HT1A receptor imaging with PET. [J] . Karramkam M, Hinnen F, Berrehouma M, Bioorganic and medicinal chemistry . 2003,第13期

机译：合成WAY-100635的（6-吡啶基-18F）标记的氟衍生物，作为PET进行脑5-HT1A受体成像的候选放射性配体。
4. SYNTHESIS OF CARBON-14 LABELED SCH 351125, A CCR5 RECEPTOR ANTAGONIST [C] . Sumei Ren. P. Rollin, P. McNamara, J. Lee, International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds . 2004

机译：CCR5受体拮抗剂的碳-14标记SCH 351125的合成
5. Synthesis and Preliminary Evaluation of an F-18 Labeled Fluoropyridine Losartan Analog as a Novel PET Tracer for Imaging AT1 Receptors [D] . Arksey, Natasha 2012

机译：F-18标记的氟吡啶氯沙坦类似物作为新型PET示踪剂，用于AT1受体成像的合成和初步评估。
6. Evaluation of 11CS14506 and 18FS14506 in rat and monkey as agonist PET radioligands for brain 5-HT1A receptors [O] . Shuiyu Lu, Jeih-San Liow, Sami S. Zoghbi, -1

机译：在大鼠和猴子中的11C S14506和18F S14506的评价为脑5-HT1A受体的激动剂宠物放射性配体
7. Evaluation of 11CS14506 and 18FS14506 in Rat and Monkey as Agonist PET Radioligands for Brain 5-HT1A Receptors [O] . Shuiyu Lu, Jeih-San Liow, Sami S. Zoghbi, 2010

机译：在大鼠和猴子中的11C S14506和18F S14506的评价为脑5-HT1A受体的激动剂宠物放射性配体

Synthesis and initial evaluation of [11C](R)-RWAY in monkey—a new, simply labeled antagonist radioligand for imaging brain 5-HT1A receptors with PET

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