Plasma protein distribution and its impact on pharmacokinetics of liposomal amphotericin B in paediatric patients with malignant diseases

Ying Hong; Peter J. Shaw; Bruce N. Tattam; Christa E. Nath; John W. Earl; Katherine R. Stephen; Andrew J. McLachlan

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Plasma protein distribution and its impact on pharmacokinetics of liposomal amphotericin B in paediatric patients with malignant diseases

机译：儿科恶性疾病患者血浆蛋白分布及其对脂质体两性霉素B药代动力学的影响

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摘要

This study investigates the association of liposomal amphotericin B (L-AmB) with plasma proteins and its impact on the pharmacokinetics of L-AmB in paediatric patients with malignant diseases.

机译：这项研究调查了脂质体两性霉素B（L-AmB）与血浆蛋白的关系及其对小儿恶性疾病患者L-AmB药代动力学的影响。

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来源
《European Journal of Clinical Pharmacology》 |2007年第2期|165-172|共8页
作者
Ying Hong; Peter J. Shaw; Bruce N. Tattam; Christa E. Nath; John W. Earl; Katherine R. Stephen; Andrew J. McLachlan;
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作者单位

Faculty of Pharmacy University of Sydney Pharmacy Building (A15) Sydney NSW 2006 Australia;

Department of Oncology The Children’s Hospital Westmead Sydney NSW Australia;

Faculty of Pharmacy University of Sydney Pharmacy Building (A15) Sydney NSW 2006 Australia;

Department of Biochemistry The Children’s Hospital Westmead Sydney NSW Australia;

Department of Biochemistry The Children’s Hospital Westmead Sydney NSW Australia;

Department of Oncology The Children’s Hospital Westmead Sydney NSW Australia;

Faculty of Pharmacy University of Sydney Pharmacy Building (A15) Sydney NSW 2006 Australia;

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原文格式 PDF
正文语种 eng
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关键词
Liposomal amphotericin B; Lipoprotein-liposome interactions; Paediatric patients; Posterior Bayesian estimates; Protein binding;

机译：脂质体两性霉素B;脂蛋白-脂质体相互作用;儿科患者;后贝叶斯估计;蛋白质结合;

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专利

1. Plasma protein distribution and its impact on pharmacokinetics of liposomal amphotericin B in paediatric patients with malignant diseases. [J] . Hong Y, Shaw PJ, Tattam BN, European journal of clinical pharmacology . 2007,第2期

机译：儿科恶性疾病患者血浆蛋白分布及其对脂质体两性霉素B药代动力学的影响。
2. Population pharmacokinetics of liposomal amphotericin B in pediatric patients with malignant diseases. [J] . Hong Y, Shaw PJ, Nath CE, Antimicrobial agents and chemotherapy. . 2006,第3期

机译：脂质体两性霉素B在儿童恶性疾病患者中的群体药代动力学。
3. Plasma protein binding of amphotericin B and pharmacokinetics of bound versus unbound amphotericin B after administration of intravenous liposomal amphotericin B (AmBisome) and amphotericin B deoxycholate. [J] . Bekersky Ihor, Fielding RobertM, Dressler DawnaE, Antimicrobial agents and chemotherapy. . 2002,第3期

机译：静脉注射脂质体两性霉素B（AmBisome）和两性霉素B脱氧胆酸盐后，两性霉素B的血浆蛋白结合以及结合的和未结合的两性霉素B的药代动力学。
4. Cytostatics as liposomal formulation-interaction with plasma proteins as determinant for pharmacokinetic behaviour [C] . Julia E.Diederichs, Jana Richter, Iduna Fichtner, International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 2000

机译：细胞抑制剂作为脂质体制剂-与血浆蛋白相互作用作为药代动力学行为的决定因素
5. Investigating the Clinical Validity of CUB and Zona Pellucidalike Domain-Containing Protein 1 (CUZD1) in Malignant and Non-Malignant Human Diseases [D] . Farkona, Sofia. 2018

机译：研究恶性和非恶性人类疾病中幼崽和Zona薄膜粒子蛋白1（CUZD1）的临床有效性
6. Plasma Protein Binding of Amphotericin B and Pharmacokinetics of Bound versus Unbound Amphotericin B after Administration of Intravenous Liposomal Amphotericin B (AmBisome) and Amphotericin B Deoxycholate [O] . Ihor Bekersky, Robert M. Fielding, Dawna E. Dressler, 2002

机译：静脉注射脂质体两性霉素B（AmBisome）和两性霉素B脱氧胆酸盐后两性霉素B的血浆蛋白结合和结合的与未结合的两性霉素B的药代动力学
7. Plasma Protein Binding of Amphotericin B and Pharmacokinetics of Bound versus Unbound Amphotericin B after Administration of Intravenous Liposomal Amphotericin B (AmBisome) and Amphotericin B Deoxycholate [O] . Bekersky, Ihor, Fielding, Robert M., Dressler, Dawna E., 2002

机译：静脉注射脂质体两性霉素B（AmBisome）和两性霉素B脱氧胆酸盐后，两性霉素B的血浆蛋白结合和结合的与未结合的两性霉素B的药代动力学

Plasma protein distribution and its impact on pharmacokinetics of liposomal amphotericin B in paediatric patients with malignant diseases

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