In vivo model of drug-induced valvular heart disease in rats: pergolide-induced valvular heart disease demonstrated with echocardiography and correlation with pathology

Steven Droogmans14 Philippe R. Franken24 Christian Garbar35 Caroline Weytjens14 Bernard Cosyns14 Tony Lahoutte24 Vicky Caveliers24 Miriam Pipeleers-Marichal35 Axel Bossuyt24 Danny Schoors1 and Guy Van Camp14

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In vivo model of drug-induced valvular heart disease in rats: pergolide-induced valvular heart disease demonstrated with echocardiography and correlation with pathology

机译：大鼠药物性瓣膜性心脏病的体内模型：超声心动图证实培高利特诱导的瓣膜性心脏病并与病理相关

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Aims Valvular heart disease (VHD), inducing valvular regurgitation, has been described in carcinoid heart disease and recently in Parkinson’s patients treated with pergolide. The aim of this study was to develop an in vivo model of drug-induced valvulopathy with pergolide in rats.

机译：目的引起瓣膜关闭不全的瓣膜性心脏病（VHD）已在类癌性心脏病中和最近在接受培高利特治疗的帕金森氏症患者中进行了描述。这项研究的目的是在大鼠中建立药物诱导的具有培高利特的瓣膜病的体内模型。

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《European Heart Journal》 |2007年第17期|2156-2162|共7页
作者
Steven Droogmans14 Philippe R. Franken24 Christian Garbar35 Caroline Weytjens14 Bernard Cosyns14 Tony Lahoutte24 Vicky Caveliers24 Miriam Pipeleers-Marichal35 Axel Bossuyt24 Danny Schoors1 and Guy Van Camp14;
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作者单位

Department of Cardiology UZ Brussel Brussels Belgium;

Department of Nuclear Medicine UZ Brussel Brussels Belgium;

Department of Pathology UZ Brussel Brussels Belgium;

In Vivo Cellular and Molecular Imaging Center (ICMIC) Vrije Universiteit Brussel (VUB) Brussels Belgium;

Experimental Pathology (EXPA) Faculty of Medicine and Pharmacy Vrije Universiteit Brussel (VUB) Brussels Belgium;

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4. Recent advances in the fluid mechanics of valvular heart disease: in vivo applications [C] . Ajit P.Yoganathan Bioengineering conference . 1999

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7. In vivo model of drug-induced valvular heart disease in rats: pergolide-induced valvular heart disease demonstrated with echocardiography and correlation with pathology [O] . S. Droogmans, P. R. Franken, C. Garbar, 2007

机译：在大鼠药物诱导的瓣膜心脏病的体内模型中：具有超声心动图和与病理学相关性证明的蠕动诱导的瓣膜心脏病

In vivo model of drug-induced valvular heart disease in rats: pergolide-induced valvular heart disease demonstrated with echocardiography and correlation with pathology

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