Acetylcholinesterase and ATPase activities in erythrocyte ghosts are not affected by 1, 2, 4-trichlorobenzene: implications for toxicity by narcotic chemicals

摘要

The membrane concentration at which 1, 2, 4-trichlorobenzene (1, 2, 4-triCBz) affects the functioning of diverse membrane proteins and the partition coefficient of 1, 2, 4-triCBz between ghosts and water were studied. Earlier studies showed that the fluidity of phospholipids is increased at concentrations of 20 to 60 mmol/kg lipid and that lethality by narcosis in an organism occurs at concentrations of 40 to 160 mmol/kg lipid, irrespective of the physicochemical properties of the nonpolar narcotic chemical.