Mammalinan and teleost cell line bioassay and chemically derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalent concentrations in lake trout (salvelinus namaycus) from lake superior and lake ontario, north america

摘要

For liver of lake trout form three Great Lakes sites, the 2,3,7,8-tetrachlorodibenzo-p-dioxin toxic equivalent (TCDD) equivalent con- centrations (TEQs) were determined in four ways. Bioassay-derived (BD) TEQs wee measured with rat (H4IIE) and rainbow trout (RTL-W1) cell lines, and chemistry-derived (CD) TEQs were calculated with TCDD equvialency factors (TEFs) derived with H4IIE and RTL-W1. Generally, BD-TEQs and CD-TEQs for individual samples did not differ significantly for either H4IIE or PTL-W1, indicating that all of the AhR-active compounds in a sample were accounted for by the congener analysis and that these compounds acted in an additive fashion in both mammalian and piscine systems.