Associations between personal exposure to air pollutants and lung function tests and cardiovascular indices among children with asthma living near an industrial complex and petroleum refineries

摘要

Objective: The acute cardiorespiratory effects of air quality among children living in areas with considerable heavy industry have not been well investigated. We conducted a panel study of children with asthma living in proximity to an industrial complex housing two refineries in Montreal, Quebec, in order to assess associations between their personal daily exposure to air pollutants and changes in pulmonary function and selected indicators of cardiovascular health. Methods: Seventy-two children with asthma age 7-12 years in 2009-2010 participated in this panel study for a period of 10 consecutive days. They carried a small backpack for personal monitoring of sulphur dioxide (SO_2), benzene, fine particles (PM_(2.5)), nitrogen dioxide (NO_2) and polycyclic aromatic hydrocarbons (PAHs) and underwent daily spirometry and cardiovascular testing (blood pressure, pulse rate and oxygen saturation). To estimate these associations, we used mixed regression models, adjusting for within-subject serial correlation, and for the effects of a number of personal and environmental variables (e.g., medication use, ethnicity, temperature). Results: Children with asthma involved in the study had relatively good pulmonary function test results (mean FEV_1 compared to standard values: 89.8%, mean FVC: 97.6%, mean FEF_(25-75): 76.3%). Median diastolic, systolic blood pressures and oxygen saturation were 60/94 mm Hg and 99%, respectively. Median personal concentrations of pollutants were NO_2, 5.5 ppb; benzene, 2.1 μg/m~3; PM_(2.5), 5.7 μg/m~3; and total PAH, 130 μg/m~3. Most personal concentrations of SO_2 were below the level of detectioa No consistent associations were observed between cardio-pulmonary indices and personal exposure to PM_(2.5), NO_2 and benzene, although there was a suggestion for a small decrease in respiratory function with total concentrations of PAHs (e.g., adjusted association with FVC: -9.9 ml per interquartile range 95%CI: -23.4, 3.7). Conclusions: This study suggests that at low daily average levels of exposure to industrial emissions, effects on pulmonary and cardiovascular functions in children with asthma may be difficult to detect over 10 consecutive days.