Urinary level of un-metabolized parabens in women working in beauty salons

摘要

Parabens are a group of chemical additive extensively utilized in various health care products and ubiquitously observed in the different environmental matrixes. Nevertheless, the exposure of women working in beauty salons to these pollutants is not well-documented. For this purpose, 50.00 women working in beauty salons were chosen as the exposed group (EG) and 35.00 housewives were chosen as the control group (GC). The concentration of methyl paraben (MeP), ethyl paraben (EtP), butyl paraben (BuP), propyl paraben (PrP), benzyl paraben (BzP), heptyl paraben (HepP), and para-hydroxybenzoic acid (4-HB) metabolite were quantified in the collected urine samples. It was seen that paraben sexist with a high detection frequency (DF) in the urine of women working in beauty salons. The results also revealed that the significant difference between the urinary parabens level in the EG and CG (P value < 0.05). The median concentration of Zparaben and HB-4 metabolite in the before exposure (BE) samples was 124.00 and 219.00 μg/L, while in the after exposure (AE) samples, it was 156.00 and 249.00 μg/L, respectively. Moreover, the parabens levels in the AE samples were considerably higher than in BE samples in women working in beauty salons (P value < 0.05). This research also documented that "personal care products (PCPs) usage" can be known as a leading factor for the urinary paraben level in the studied individuals. The median total estimated daily intakes (TEsDI) for MeP, EtP, and PrP for the studied women were obtained as 8.02, 4.57, and 7.88 μg/L respectively. Also, a significant and positive association was observed between EtP, PrP as well as BuP and 8-OhdG (as a DNA oxidative stress biomarker) (P value < 0.01). Further, a significant and positive association was found between EtP as well as BuP and some biomarkers of kidney damage (like uTIMP-1 and uKim-1). Accordingly, it can be stated that women working in beauty salons are at a high risk in terms of DNA oxidative stress and kidney damage.