Sensitivity of the zebrafish (Danio rerio) early life stage test for compounds with different modes of action

摘要

The sensitivity of the early life stage (ELS) toxicity test for two compounds with different modes of action was determined, and related to other toxicity tests with the same compounds. The zebrafish, Danio rerio, was used as a test organism, and the two model compounds were 1,2,3-trichlorobenzene (123TCB), a non-polar narcotic, and parathion, an acetylcholinesterase (AChE) inhibitor Hatching and survival after 28 days were significantly reduced in the highest 123 TCB treatment (263 μg/l), but not in any of the Parathion treatments. Growth of the larvae was negatively affected at parathion concentrations above 20 μg/l, while AChE was Only significantly inhibited at the highest concentration, 93 μg/l.