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A crossover-crossback prospective study of dibutyl-phthalate exposure from mesalamine medications and semen quality in men with inflammatory bowel disease

机译:炎症性肠病男性美沙拉敏药物与邻苯二甲酸二丁酯接触及精液质量的交叉-交叉前瞻性研究

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摘要

Background: Phthalates are widely used chemicals with ubiquitous exposure. Dibutyl-phthalate (DBP), a male reproductive toxicant in animals, is understudied in humans. Some mesalamine medications used to treat inflammatory bowel disease (IBD) have DBP in their coating, whereas other mesalamine formulations do not. Objectives: Taking advantage of differences in mesalamine formulations, we investigated whether high-DBP exposure from mesalamine medications was associated with decreased semen parameters.
机译:背景:邻苯二甲酸酯是广泛使用的,普遍存在的化学品。邻苯二甲酸二丁酯(DBP)是一种动物中的雄性生殖有毒物质,但在人类中的研究尚不足。一些用于治疗炎症性肠病(IBD)的美沙拉敏药物的涂层中含有DBP,而其他美沙拉敏配方则没有。目的:利用美沙拉敏配方的差异,我们调查了美沙拉敏药物的高DBP暴露是否与精液参数降低有关。

著录项

  • 来源
    《Environment international》 |2016年第10期|120-130|共11页
  • 作者单位

    Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, 665 Huntington Ave,Bldg 1,Room 1406, Boston, MA 02115 USA;

    Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA;

    Rigshosp, Univ Dept Growth & Reprod, Copenhagen, Denmark;

    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;

    Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, 665 Huntington Ave,Bldg 1,Room 1406, Boston, MA 02115 USA;

    Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, 665 Huntington Ave,Bldg 1,Room 1406, Boston, MA 02115 USA;

    Wayne State Univ, Dept Obstet & Gynecol, Ctr Mol Med & Genet, Detroit, MI USA;

    Harvard Med Sch, Childrens Hosp Boston, Div Gastroenterol, Boston, MA USA;

    Harvard Med Sch, Brigham & Womens Hosp, Div Gastroenterol Hepatol & Endoscopy, Boston, MA USA;

    Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Inflammatory Bowel Dis, Boston, MA USA;

    Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, 665 Huntington Ave,Bldg 1,Room 1406, Boston, MA 02115 USA;

    Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, 665 Huntington Ave,Bldg 1,Room 1406, Boston, MA 02115 USA|Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA|Massachusetts Gen Hosp, Vincent Obstet & Gynecol, Boston, MA 02114 USA|Harvard Med Sch, Boston, MA USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Phthalates; Mesalamine; Inflammatory bowel disease (IBD); Semen quality;

    机译:邻苯二甲酸盐;美沙拉敏;炎性肠病(IBD);精液质量;

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