TREX-2 complex is responsible for general mRNA export from nucleus to cytoplasm in eukaryote. The main protein of TREX-2 complex of D. melanogaster is protein Xmas-2. Its homologues in yeast and humans are Sac3 and GANP proteins, respectively. All three proteins contain the highly conserved domain Sac3-GANP, which is essential for interaction of TREX-2 complex with mRNA and another protein of the complex, PCID2. We identified two Xmas-2 homologues in D. melanogaster using the Sac3-GANP family domain sequence. These proteins have a common domain responsible for interaction with the PCID2 protein and RNA and are present in other eukaryotes. The function of these proteins is unknown. However, on the basis of their structural organization, we can assume that they interact with nucleic acids.
展开▼
机译:TREX-2复合体负责一般MRNA从真核生物中的细胞核导出到细胞质。 D. melanogaster的Trex-2络合物的主要蛋白质是蛋白质xmas-2。其在酵母和人类的同源物分别是SAC3和GANP蛋白。所有三种蛋白质含有高度保守的结构域SAC3-GANP,这对于TREX-2复合物与MRNA和复合物的另一种蛋白质的相互作用至关重要。我们使用SAC3-GANP家族域序列鉴定了D. melanogaster的两种XMAS-2同源物。这些蛋白质具有负责与PCID2蛋白和RNA相互作用的常见结构域,并存在于其他真核中。这些蛋白质的功能是未知的。然而,在其结构组织的基础上,我们可以假设它们与核酸相互作用。
展开▼