Pharmacological and Physicochemical Properties of Mechanochemically Synthesized Supramolecular Complexes of Acetylsalicylic Acid and Polysaccharide Arabinogalactan from Larches Larix sibirica and Larix gmelinii

摘要

In effective complex therapy of cardiovascular diseases, a major role is played by antithrombotic drugs, the most popular of which are based on acetylsalicylic acid (ASA) medicines [1]. Given the fact that the use of ASA for primary and secondary prevention of cardiovascular diseases is a lifetime measure, the risk of development of adverse side effects, inherent in almost every drug, increases. The most frequent clinically significant side effect of ASA is the irritation of gastric membranes of the gastrointestinal tract, including the formation of erosions and ulcers (the so-called ulcero-genic effect) [2]. Special studies have shown that this effect depends on the dose of ASA.