Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms

S. A. Sch?fer; O. Tschritter; F. Machicao; C. Thamer; N. Stefan; B. Gallwitz; J. J. Holst; J. M. Dekker; L. M. t’Hart; G. Nijpels; T. W. van Haeften; H. U. H?ring; A. Fritsche

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Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms

机译：转录因子7样2（TCF7L2）基因多态性携带者中胰高血糖素样肽1诱导的胰岛素分泌受损。

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Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes and reduced insulin secretion. The transcription factor TCF7L2 is an essential factor for glucagon-like peptide-1 (GLP-1) secretion from intestinal L cells. We studied whether a defect in the enteroinsular axis contributes to impaired insulin secretion in carriers of TCF7L2 polymorphisms.

机译：转录因子7样2（TCF7L2）基因中的多态性与2型糖尿病和胰岛素分泌减少有关。转录因子TCF7L2是肠L细胞分泌胰高血糖素样肽1（GLP-1）的必需因子。我们研究了肠小肠轴上的缺陷是否导致TCF7L2多态性携带者胰岛素分泌受损。

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来源
《Diabetologia》 |2007年第12期|2443-2450|共8页
作者
S. A. Sch?fer; O. Tschritter; F. Machicao; C. Thamer; N. Stefan; B. Gallwitz; J. J. Holst; J. M. Dekker; L. M. t’Hart; G. Nijpels; T. W. van Haeften; H. U. H?ring; A. Fritsche;
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作者单位

Division of Endocrinology Diabetology Vascular Medicine Nephrology and Clinical Chemistry Department of Internal Medicine Eberhard-Karls University of Tübingen Otfried-Müller-Str. 10 72076 Tübingen Germany;

Division of Endocrinology Diabetology Vascular Medicine Nephrology and Clinical Chemistry Department of Internal Medicine Eberhard-Karls University of Tübingen Otfried-Müller-Str. 10 72076 Tübingen Germany;

Division of Endocrinology Diabetology Vascular Medicine Nephrology and Clinical Chemistry Department of Internal Medicine Eberhard-Karls University of Tübingen Otfried-Müller-Str. 10 72076 Tübingen Germany;

Division of Endocrinology Diabetology Vascular Medicine Nephrology and Clinical Chemistry Department of Internal Medicine Eberhard-Karls University of Tübingen Otfried-Müller-Str. 10 72076 Tübingen Germany;

Division of Endocrinology Diabetology Vascular Medicine Nephrology and Clinical Chemistry Department of Internal Medicine Eberhard-Karls University of Tübingen Otfried-Müller-Str. 10 72076 Tübingen Germany;

Division of Endocrinology Diabetology Vascular Medicine Nephrology and Clinical Chemistry Department of Internal Medicine Eberhard-Karls University of Tübingen Otfried-Müller-Str. 10 72076 Tübingen Germany;

Department of Medical Physiology Panum Institute University of Copenhagen Copenhagen Denmark;

On behalf of the Hoorn study EMGO Institute Vrije Universiteit Medical Center Amsterdam the Netherlands;

Department of Molecular Cell Biology Leiden University Medical Center Leiden the Netherlands;

On behalf of the Hoorn study EMGO Institute Vrije Universiteit Medical Center Amsterdam the Netherlands;

Department of Internal Medicine Utrecht University Medical Center Utrecht the Netherlands;

Division of Endocrinology Diabetology Vascular Medicine Nephrology and Clinical Chemistry Department of Internal Medicine Eberhard-Karls University of Tübingen Otfried-Müller-Str. 10 72076 Tübingen Germany;

Division of Endocrinology Diabetology Vascular Medicine Nephrology and Clinical Chemistry Department of Internal Medicine Eberhard-Karls University of Tübingen Otfried-Müller-Str. 10 72076 Tübingen Germany;

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正文语种 eng
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关键词
GLP-1; Insulin secretion; Polymorphism; TCF7L2;

机译：GLP-1;胰岛素分泌;多态性;TCF7L2;

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专利

1. Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms [J] . S. A. Schäfer, O. Tschritter, F. Machicao, Diabetologia . 2009,第3期

机译：转录因子7样2（TCF7L2）基因多态性携带者中胰高血糖素样肽1诱导的胰岛素分泌受损。
2. Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms [J] . S. A. Schäfer, O. Tschritter, F. Machicao, Diabetologia . 2008,第1期

机译：转录因子7样2（TCF7L2）基因多态性携带者中胰高血糖素样肽1诱导的胰岛素分泌受损。
3. Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance. [J] . Damcott CM, Pollin TI, Reinhart LJ, Diabetes . 2006,第9期

机译：转录因子7样2（TCF7L2）基因中的多态性与阿米什语中的2型糖尿病有关：复制和证据都在胰岛素分泌和胰岛素抵抗中起作用。
4. Impaired insulin secretion in perfused pancreases isolated from offspring of protein malnourished rats [C] . M.P.G. BARNETT, A.R.J. PHILLIPS, P.M. HARRIS, Conference of the New Zealand Society of Animal Production . 2006

机译：从蛋白质营养大鼠的后代分离的灌注胰腺中的胰岛素分泌受损
5. The influence of insulin-like growth factor pathway gene polymorphisms on the strength training response of muscle phenotypes in older adults. [D] . Hand, Brian Dudley. 2006

机译：胰岛素样生长因子途径基因多态性对老年人肌肉表型力量训练反应的影响。
6. Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms [O] . S. A. Schäfer, O. Tschritter, F. Machicao, -1

机译：转录因子7样2（TCF7L2）基因多态性携带者中胰高血糖素样肽1诱导的胰岛素分泌受损。
7. Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms [O] . Schäfer, S. A., Tschritter, O., Machicao, F., 2009

机译：转录因子7样2（TCF7L2）基因多态性携带者中胰高血糖素样肽1诱导的胰岛素分泌受损。

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms

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