Brief Genetics Report: Variant in the Regulatory Subunit of Phosphatidylinositol 3-Kinase (p85α) Preliminry Evidence Indicates a Potential Role of This Variant in the Acute insulin Response and Type 2 Diabetes in Pima Women

摘要

Phosphatidylinositol 3-kinase (PI 3-kinase), a sig- naling molecule activated by insulin receptor sub- strate (IRS)-1, has a role in both insulin-stimulated glucose uptake and in basal glucose transporter recycling. PI 3-kinase is also responsible for phosphorylating phospahtidylinositol, PI-4-P, PI-4,5-P_2, and PI-3,4,5-P_3, which function as intracellular second messengers. The structure of PI 3-kinase is heterodimeric, consisting of a catalytic subunit (p110) and a regulatory submunit, which is one of several alter- natively spliced products of the p85αgene (GRB1) (1).