Severe Leptin Resistance in Brown Fat-Deficient Uncoupling protein Promoter-Driven Diphtheria Toxin A Mice Despite Suppression of Hypothalamic Neuropeptide Y and Circulating Corticosterone Concentrations

摘要

Brwon adipose tissue (BAT) has the capacity for uncou- pled mitochondrial respiration and is proposed to be a key site for regulating energy expenditure in rodents. To better define the role of BAT in energy homeostasis, We previously recreated a line of transgenic mice with Deficiency of BAT (UCP promoter-driven diphtheria Toxin A transgenic mice [UCP-DTA]) mice. These mice Develop obesity that initially is due to decreased Energy expenditure and later accompanied by hyper- Phagia despite increased levels of circulating leptin.