cAMP Enhances Insulin Secretion by an Action on the ATP-Sensitive K+ Channel-Independent Pathway of Glucose Signaling in Rat Pancreatic Islets

摘要

Cyclic AMP potentiates glucose-stimulated insulin release by actions predominantly at a site, or sites, distal to the elevation of the cytosolic free Ca~2+ con- centration ([Ca~2+]I). Glucose also acts at a site, or sites, distal to the elevation of [Ca~2+]I via the ATP- sensitive K+ channel (K+ATP channel)independent signaling pathway. Accordingly, using rat pancreatic islets, we studied the location of the action of cAMP and its interaction with the glucose pathway.