Association of Polymorphism in the NeuroD/BETA2 Gene With Type 1 Diabetes in the Japanese

摘要

NeuroD/BETA2, a transcription factor of the insulin gene, also plays an important role in the development of pan- creatic β-cells. Recently, the NeuroD/BETA2 gene has been mapped to the long arm of human chromosome 2 (2q32) where the IDDM7 gene has previously been mapped, imply- ing its involvement in diabetes. To identify mutations in the NeuroD/BETA2 gene that may predispose patients to Develop diabetes, we studied the gene in 50 Japanese sub- Jects with diabetes (4 with type 1 and 46 with tykpe 2) by the Polymerase chain reaction (PCR) followed by single-strand Conformation polymorphism and sequencing analyses.