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首页> 外文期刊>Diabetes >Expression of the NH^sub 2^-Terminal Fragment of RasGAP in Pancreatic [beta]-Cells Increases Their Resistance to Stresses and Protects Mice From Diabetes
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Expression of the NH^sub 2^-Terminal Fragment of RasGAP in Pancreatic [beta]-Cells Increases Their Resistance to Stresses and Protects Mice From Diabetes

机译：RasGAP的NH 2亚端的2′末端片段在胰腺β细胞中的表达增加了它们对应激的抵抗力并保护了小鼠免受糖尿病的侵害

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摘要

Our laboratory has previously established in vitro that a caspase-generated RasGAP NH(2)-terminal moiety, called fragment N, potently protects cells, including insulinomas, from apoptotic stress. We aimed to determine whether fragment N can increase the resistance of pancreatic beta-cells in a physiological setting.
机译：我们的实验室以前已经在体外建立了一个称为片段N的caspase生成的RasGAP NH（2）末端部分，可以有效地保护细胞（包括胰岛素瘤）免受细胞凋亡的压力。我们旨在确定片段N是否可以在生理环境中增加胰腺β细胞的抗性。

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  • 来源
    《Diabetes》 |2009年第11期|p.2596-2606|共11页
  • 作者

    Jiang-Yan Yang Joel Walicki Evrim Jaccard Gilles Dubuis Natasa Bulat Jean-Pierre Hornung Bernard Thorens Christian Widmann;

  • 作者单位

    Jiang- Yan Yang,1-2 Jöel Walicki,1'2 Evrim Jaecard,1,2 Gilles Dubois,1'2 Natasa Bnlat,1,2 Jean-Pierre Hornung,2 Bernard Thorens,1,3 and Christian Widmann1'2From the 1 Department of Physiology, University of Lausanne, Lausanne, Switzerland: the '1 iepartmenl of Cell Biology and Morphology. University of Lausanne. Lausanne. Switzerland, and the Center for hitegrative Genomics, Genopode Building, University of Lausanne, Lauisanne. Switzerland.Corresponding author: Christian Widmann, christian. widniann@unil.ch.Received 22 January 2009 and accepted 2 August 2009. Published ahead of print al http://diabete.s.diabetesjournals.org on 20 August 2009. I)OI: 10.2337/db09-0104.J.-Y.Y., J.W.. and EJ, contributed equally to this article.© 2009 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativeconuiions.org/licenses/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore he hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicator this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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  • 正文语种 eng
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  • 入库时间 2022-08-17 13:45:55

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