机译:单基因糖尿病转录因子HNF-1α和HNF-4α的功能靶标在小鼠和人类之间高度保守。
Sylvia F. Boj,1 Joan Marc Servitja,1 David Martin,2 Martin Rios,3 Iannis Talianidis,4 Roderic Guigo,2 and Jorge Ferrer1'5From the 1 Genomic Programming of Beta-cells Laboratory, Institut d'lnvestigacions Biomèdiques August Pi i Sunyer, and Endocrinology, Hospital Clinic de Barcelona, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólieas Asociadas, Barcelona, Spain, the 2 Center for Genomic Regulation, Barcelona, Spain, the 3 Department of Statistics, University of Barcelona School of Biology, Barcelona, Spain, and the 4 Biomedical Sciences Research Center Alexander Fleming, Athens, Greece.Corresponding author: Jorge Ferrer, jferrer@clinic.ub.es.Received 18 June 2008 and accepted 20 January 2009.Published ahead of print at http://diabetes.diabetesjournals.org on 10 February 2009. DOI: 10.2337/db08-0812.S.F.B. and J.M.S. contributed equally to this work.© 2009 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by -nc-nd#.0/ for details.The costs of publication of this article were defrayed in jiart by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.,;
机译:肝细胞核因子(HNF)-4 alpha /γ和HNF-1 alpha协同调节人类二氢二醇脱氢酶(DD)4 /醛基酮还原酶(AKR)1C4基因的转录
机译:动力学稳定性可能会决定双功能蛋白DCoH1(转录因子HNF-1 alpha的二聚化辅助因子)的相互作用动力学
机译:肝细胞核因子(HNF)-1alpha,-4alpha,-1beta和-3beta基因突变; HNF-1的二聚化辅因子;在皮马印第安人中,胰岛素和促胰岛素因子1不是2型糖尿病早期发作的常见原因。
机译:缺乏过氧化合物酶体增殖物激活受体-α(PPAR-α)正常MiCeand中脂肪生成和胆固基因表达的功能效率
机译:盐敏感性高血压中脑钠钾ATP酶α2同工型的作用:基因靶向杂合α2钠钾ATP酶敲除小鼠对增强的CSF钠和哇巴因浓度的升压反应。
机译:单基因糖尿病转录因子HNF-1α和HNF-4α的功能靶标在小鼠和人类之间高度保守。
机译:单基因糖尿病转录因子HNF-1α和HNF-4α的功能靶标在小鼠和人类之间高度保守。