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首页> 外文期刊>Diabetes >Interaction Effect of Genetic Polymorphisms in Glucokinase (GCK) and Glucokinase Regulatory Protein (GCKR) on Metabolic Traits in Healthy Chinese Adults and Adolescents
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Interaction Effect of Genetic Polymorphisms in Glucokinase (GCK) and Glucokinase Regulatory Protein (GCKR) on Metabolic Traits in Healthy Chinese Adults and Adolescents

机译：葡萄糖激酶（GCK）和葡萄糖激酶调节蛋白（GCKR）基因多态性对健康成年人和青少年代谢性状的相互作用

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摘要

Recent studies in European populations have reported a reciprocal association of glucokinase regulatory protein (GCKR) gene with triglyceride versus fasting plasma glucose (FPG) levels and type 2 diabetes risk. GCKR is a rate-limiting factor of glucokinase (GCK), which functions as a key glycolytic enzyme for maintaining glucose homeostasis. We examined the associations of two common genetic polymorphisms of GCKR and GCK with metabolic traits in healthy Chinese adults and adolescents.
机译：欧洲人群的最新研究报告了葡萄糖激酶调节蛋白（GCKR）基因与甘油三酸酯的相互关系与空腹血糖（FPG）水平和2型糖尿病风险之间的相互关系。 GCKR是葡萄糖激酶（GCK）的限速因子，它是维持葡萄糖稳态的关键糖酵解酶。我们研究了健康中国成年人和青少年中两种常见的GCKR和GCK基因多态性与代谢性状的关系。

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  • 来源
    《Diabetes》 |2009年第3期|p.765-769|共5页
  • 作者

    Claudia H T Tam Ronald C W Ma Wing Yee So Ying Wang Vincent K L Lam Soren Germer Mitchell Martin Juliana C N Chan Maggie C Y Ng;

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    Claudia H.T. Tarn,1 Ronald CW. Ma,1 Wing Yee So,1 Ying Wang,1 Vincent K.L. Lam,1 Soren Germer,2 Mitchell Martin,2 Juliana CN. Chan,1,3,4 and Maggie CY. Ng1From the 'Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China, 2Roche Pharmaceuticals, Nutiey, New Jersey, the 3Li Ka Shing institute of Health Sciences, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong +Kong, China, the 4Hong Kong Institute of Diabetes and Obesity, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, ChinaCorresponding author: Juliana CN. Chan, jchan@cuhk.edu.hk.Received 16 September 2008 and accepted 5 December 2008.Published ahead of print at http://diabetes.diabetesjournals.org on 10 December 2008. DOI: 10.2337/db08-1277.© 2009 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/Ucenses/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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