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Monocyte Gene-Expression Profiles Associated With Childhood-Onset Type 1 Diabetes and Disease Risk: A Study of Identical Twins

机译：与儿童期1型糖尿病和疾病风险相关的单核细胞基因表达谱：相同双胞胎的研究

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摘要

Monocytes in childhood-onset type 1 diabetes show distinct gene expression. We hypothesize that monocyte activation in monozygotic (MZ) twin pairs discordant for childhood-onset type 1 diabetes could reflect distinct stages of the disease process including diabetes susceptibility (differences between twins, both diabetic and nondiabetic, and control subjects) and/or disease progression (differences between diabetic and nondiabetic twins).
机译：儿童期1型糖尿病的单核细胞显示出独特的基因表达。我们假设单合子（MZ）双胞胎对中与儿童期1型糖尿病不一致的单核细胞激活可能反映了疾病过程的不同阶段，包括糖尿病易感性（双胞胎之间的差异，糖尿病和非糖尿病与对照组之间的差异）和/或疾病进展（糖尿病和非糖尿病双胞胎之间的差异）。

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  • 来源
    《Diabetes》 |2010年第7期|p.1751-1755|共5页
  • 作者

    Huriya Beyan Roosmarijn C Drexhage Leonie van der Heul Nieuwenhuijsen Harm de Wit Roosmarijn C Padmos Nanette C Schloot Hemmo A Drexhage Richard David Leslie;

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    Huriya Beyan,1 Roosmarijn C. Drexhage,2 Leonie van der Heul Nieuwenhuijsen,2 Harm de Wit,2 Roosmarijn C. Padmos,2 Nanette C. Schloot,3 Hemmo A. Drexhage,2 and Richard David Leslie1From tlie 'Blizard Institute of Cell and Molecular Science, Queen Mary. University of London, London, U.K., the department of Immunology. Erasmus Medical Center, Rotterdam, the Netherlands, and the 'Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine University Dusseldorf and the Department of Medicine/Metabolic Diseases. University Hospital, Düsseldorf, Germany.Corresponding author: Richard David Leslie, r.d.g.leslie@qmul.ac.uk.Received 28 September 2009 and accepted 26 March 2010. Published ahead of print al http://diabetes.diabetes.journals.org on 14 April 2010. DOI: 10.2337/dbQ9-1433.H. B. and RCD. conlribuled equally lo Ibis article.© 2010 by die American Diabetes Association. Readers may use Ulis article as long as the work is properly cited, the use is educational and not for profit, and the work is noi altered. See http://creativecommons.org/Ucenses/by -nc-nd/3.0/ for details.The casts of publication of this article were defrayed in part by the payment oj pagi charges. This article must therefore be hereby marked "advertisement" in accord, nm with 18 U.S.C. Section 1734 solely to indicane thus fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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  • 入库时间 2022-08-17 13:45:43

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