...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Diabetes >TBC1D1 Regulates Insulin- and Contraction-Induced Glucose Transport in Mouse Skeletal Muscle
【24h】

TBC1D1 Regulates Insulin- and Contraction-Induced Glucose Transport in Mouse Skeletal Muscle

机译：TBC1D1调节小鼠骨骼肌中胰岛素和收缩诱导的葡萄糖转运。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

TBC1D1 is a member of the TBC1 Rab-GTPase family of proteins and is highly expressed in skeletal muscle. Insulin and contraction increase TBC1D1 phosphorylation on phospho-Akt substrate motifs (PASs), but the function of TBC1D1 in muscle is not known. Genetic linkage analyses show a TBC1D1 R125W missense variant confers risk for severe obesity in humans. The objective of this study was to determine whether TBC1D1 regulates glucose transport in skeletal muscle.
机译：TBC1D1是TBC1 Rab-GTPase蛋白质家族的成员，在骨骼肌中高度表达。胰岛素和收缩增加了磷酸化Akt底物基序（PAS）上的TBC1D1磷酸化，但是尚不知道TBC1D1在肌肉中的功能。遗传连锁分析显示，TBC1D1 R125W错义变体赋予人类严重肥胖的风险。这项研究的目的是确定TBC1D1是否调节骨骼肌中的葡萄糖转运。

著录项

  • 来源
    《Diabetes 》 |2010年第6期| p.1358-1365| 共8页
  • 作者

    Ding An Taro Toyoda Eric B Taylor Haiyan Yu Nobuharu Fujii Michael F Hirshman Laurie J Goodyear;

  • 作者单位

    Ding An,1 Taro Toyoda,1 Eric B. Taylor,1 Haiyan Yu,1 Nobuharu Fujii,1 Michael F. Hirshman,1 and Laurie J. Goodyear1,2From the 1 Research Division, Joslin Diabetes Center, Boston, Massachusetts, and the 2 Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.Corresponding author Laurie J. Goodyear, laurie.goodyear@joslin.harvard.edu.Received 26 August 2009 and accepted 2 March 2010. Published ahead of print at http://diabetes.diabetesjournals.org on 18 March 2010. DOI: 10.2337/ db09-1266.© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not. for profit, and the work is not altered. See http://creativecommons.org/licenses/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by tile payment of page charges. Tliis article must therefore be fiereby marked "advertisement" in accordance ufith 18 U.S.C Section 1734 solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号