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Unacylated Ghrelin Rescues Endothelial Progenitor Cell Function in Individuals With Type 2 Diabetes

机译:未酰化的Ghrelin挽救2型糖尿病患者的内皮祖细胞功能。

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摘要

Acylated ghrelin (AG) is a diabetogenic and orexigenic gastric polypeptide. These properties are not shared by the most abundant circulating form, which is unacylated (UAG). An altered UAG/AG profile together with an impairment of circulating endothelial progenitor cell (EPC) bioavailability were found in diabetes. Based on previous evidence for the beneficial cardiovascular effects of AG and UAG, we investigated their potential to revert diabetes-associated defects.
机译:酰化的生长素释放肽(AG)是一种糖尿病和食源性胃多肽。这些特性未被未酰化的最丰富的循环形式所共享。在糖尿病中发现UAG / AG谱改变以及循环内皮祖细胞(EPC)生物利用度受损。基于AG和UAG对心血管的有益心血管作用的先前证据,我们研究了它们逆转与糖尿病相关的缺陷的潜力。

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  • 来源
    《Diabetes》 |2010年第4期|p.1016-1025|共10页
  • 作者单位

    Gabriele Togliatto,1 Antonella Trombetta,1 Patrizia Dentelli/ Alessandra Baragli,1 Arturo Rosso,1 Riccarda Granata,1 Dario Ghigo,2 Luigi Pegoraro,1 Ezio Ghigo,1 and Maria Felice Brizzi1Frora the 1 Department of Internal Medicine, University of Torino, Torino, Italy, and the 2 Department of Genetics. Biology and Biochemistry, University of Torino, Torino, Italy.Corresponding authors: Maria Felice Brizzi, mariafelice.brizzi@unito.it, and Ezio Ghigo, ezio.ghigo@unito.it,Received 8 June 2009 and accepted 3 January 2010. Published ahead of print at http://diabetes.diabetesjournals.org on 12 January 2010. DOI: 10.2337/db09-0858.G.T. and A.T. contributed equally to this study.© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecomnions.org/licenses/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by the payment of paye charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 17Sk solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 入库时间 2022-08-17 13:45:39

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