The Q allele variant(GLN~121)of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant(LYS~121)

摘要

When overexpressed, the membrane glycoprotein PC-1 may play a role in human insulin resistance through the inhibition of insulin receptor(IR)autophosphorylation. A PC-1 variant(K~121 A, with lysine 121 replaced by gluta- Mine)is also associated with whole-body insulin resis- Tance when not overexpressed. To better understand the Effects of the Q allele on IR function and downstream Signaling, we transfected cultured cells with cDNAs for Either the Q or the K alleles.