Effect of vagal cooling on the counterrgulatory response to hypoglycemia induced by a low dose of insulin in the conscious dog

摘要

We previously demonsrated, using a nerve-cooling technique, that the vagus nerves are not essential for the counterregulatory response to hypoglycemia caused by high levels of insulin. Because high insulin levels per se augment the central nervous system response to hypoglycemia, the question arises whether afferent nerve fibers traveling along the vagus nerves would play a role in the defense of hypoglycemia in the presence of a more moderate insulin level. To address this issue, we studied two groups f conscious 18-h-fasted dogs with cooling coils previously placed on both vagus nerves.