Type 1 diabetes manifested solely by 2-h oral glucose tolerance test criteria

摘要

The clinical presentation of type 1 diabetes usually involves symptoms such as polyuria and polydipsia. However, investigators in the Diabetes Prevention Trial Of Type 1 Diabetes(DPT-1)have detected a group of Subjects with type 1 diabetes who have a different phe- Notype. These subjects are asymptomatic, have normal (<6.1 mmol/l)(group A)or impaired(6.1-<7.0 mmol/l) (group B)fasting glucose, but have 2-h glucose values >11.1 mmol/l on their oral, glucose tolearance tests (OGTT). Of the 585 OGTTs performed on islet cell anti- body(ICA)-positive relatives with insulin autoanti- bodies(IAA)or low first-phase insulin response (FPIR), normal glucose tolerance(NGT)was found in 427 subjects; impaired glucose tolerance(IGT)was found in 87 subjects, and diabetes was found by 2-h OGTT criteria along in 61 subjects.