Rapid publication ghrelin, and endogenous growth, hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway

摘要

Ghrelin, and endogenous ligand for growth hormone sec- retagogue(GHS)receptor originally isolated from the stomach, occurs in the hypothalamic arcuate nucleus and may play a role in energy homeostasis. Synthetic GHSs have activated the hypothalamic arcuate neurons Containing neuropeptide Y(NPY), suggesting the Involvement of NPY in some of ghrelin actions. This Study was designed to elucidate the role of ghrelin in the Regulation of food intake.