A genome-wide scan for loci linked to plasma levels of glucose and HbA_1c in a community-based sample of caucasian pedigress the framingham offspring study

摘要

Elevated blood glucose levels are the hallmark of type 2 diabetes as well as a powerful risk factor for develop- ment of the disease. We conducted a genome-wide search for diabetes-related genes, using measures of glycemia as quantitative traits in 330 pedigrees from the Framingham Heart Study. Of 3,799 attendees at the 5th Offspring Study exam cycle(1991-1995), 1,461, 1,251, and 771 men(49/100)and women provided infor- mation on levels of 20-year mean fasting glucose, cur- rent fasting glucose, and HbA_1c, respectively, and 1,308 contributed genotype data(using 401 microstallite markers with an average spacing of 10 cM).