Oral exposure to diabetes-promoting food or immunomodulators in neonates alters gut cytokines and diabetes

摘要

Disease development in diabetes-prone BB rats is mod- ified by the type of diet fed after weaning. The aim of this investigation was to determine whether exposure during the first week of life to antigens from a known diabetes-promoting diet(NIH-07)could modify diabe- tes incidence and, if so, to what extent this occurs via alterations in systemic T-cell reactivity, gut cytokines, or islet infiltration. Diabetes-prone BB(BBdp)rats were hand-fed twice daily between age 4 and 7 days with vehicle, a hydrolyzed casein(HC)-based infant formula, Pregestimil(PG), PG + cereal-based NIH-07 diet, PG + Lipopolysaccharides(LPS)or PG + LPS + silica.