Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion

摘要

Obesity is frequent cause of insulin resistance and poses a major risk for diabetes. Abnormal fat deposition within skeletal muscle has been identified as a mecha- nism of obesity-associated insulin resistance. We tested the hypothesis that dietary lipid deprivation may selec- tively deplete intramyocellular lipids, thereby reversing insulin resistance. Whole-body insulin sensitivity(by the insulin clamp technique), intramyocellular lipids (by quantitative histochemistry on quadriceps muscle biopsies), muscle insulin action(as the expression of Glut4 glucose transporters), and postprandial lipemia Were measured in 20 morbidly obese patients(BMI = 49±8[mean ± SD]kg.mQ-2)and 7 nonobese control subjects.