Transplantation-Mediated Host B-Cell Depletion Mitigates Autoimmunity in Mice

摘要

An article by Racine et al. in this issue of Diabetes (p. 2051) investigates how hematopoietic cell transplantation (HCT) impacts type 1 diabetes in mice, with a focus on the role of major histocompatibility complex (MHC)-mismatched mixed chimerism in tolerizing autoreactive B lymphocytes. It is well-known that MHC plays a significant role in determining an individual's susceptibility to type 1 diabetes, as well as other autoimmune disorders. The new study, which builds on previous research by the same group, involved a transplant group that received nonmyeloablative conditioning and transplantation of donor T-cell-depleted spleen and whole bone marrow cells. The control group received conditioning only.