It's Time to Bring Dendritic Cell Therapy to Type 1 Diabetes

摘要

Despite many overlapping features between the mouse and human T1D (1), a substantial genetic heterogeneity as well as differential environmental exposures exists among humans developing T1D, and the sum of these genetic and environmental factors determines disease progression and the onset of hyperglycemia, whereas NOD mice are genetically uniform animals and are housed in environmentally similar conditions. It is therefore easier to prevent T1D progression in NOD mice using treatments, including DC-based approaches, at disease stages that are well defined.