A Weighty Matter: Can PUFAs in Pregnancy Prevent Obesity?

摘要

The prevalence of overweight and obesity has increased around the world and across all age-groups. In addition to reductions in physical activity and increases in the energy, sugar, and fat content of the diet, other contributors acting in early life are increasingly recognized, such as maternal obesity, gestational diabetes mellitus, antibiotic exposure, and maternal diet. Recendy, in high-fat diet rodent models of maternal obesity, lowering the maternal ratio of n-6 to n-3 fatty acids using a novel genetic model or supplemental fish oil has been shown to prevent offspring obesity (1) and development of insulin resistance (1,2).