首页> 外文期刊>Journal of Dental Sciences >Safety and feasibility assessment of biodegradable poly ( l-lactic acid/ε-caprolactone) membrane for guided bone regeneration: A case series of first-in-human pilot study
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Safety and feasibility assessment of biodegradable poly ( l-lactic acid/ε-caprolactone) membrane for guided bone regeneration: A case series of first-in-human pilot study

机译:可生物降解的多( l - 乳酸/ε-己内酯)膜的安全性和可行性评估用于引导骨再生的膜:案例系列一系列第一赛季试验研究

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Background/purposeGuided bone regeneration (GBR) is the most popular technique for alveolar ridge augmentation in implant dentistry, and resorbable cell barrier membrane, made of collagen, is widely used. We tried to develop a new resorbable cell barrier membrane from an animal-free product. This study aimed to investigate the safety and feasibility for clinical application of poly (l-lactic acid/ε-caprolactone) [P (LA/CL)] membrane, a novel biodegradable synthetic material used for GBR.Materials and methodsPatients who required horizontal bone augmentation (≥3?mm implant exposure) for implant treatment were included in the study. P (LA/CL) membrane was used simultaneously with implant placement to achieve bone augmentation by GBR. The occurrence of adverse events was assessed until the follow-up period of a second surgical procedure. The amount of bone augmentation was assessed by means of cone-beam computed tomography, and implant stability was assessed by measuring the implant stability quotient (ISQ). Student'st-test was used and the level of significance was set at p?
机译:背景/临床骨再生(GBR)是植入物牙科在植入物牙科的增强技术最流行的技术,并且广泛使用由胶原蛋白制成的可再吸收的电池阻挡膜。我们试图从无动物产品开发一种新的可再吸收的细胞屏障膜。本研究旨在探讨聚(L-乳酸/ε-己内酯)临床应用的安全性和可行性[P(LA / CL)]膜,一种用于GBR的新型可生物降解的合成材料。方法和方法等分列研究中包括增强(≥3?mm植入植入暴露)。 P(La / Cl)膜同时使用植入物放置,以通过GBR实现骨增强。评估不良事件的发生直至第二次外科手术的后续期。通过锥梁计算断层扫描评估骨增强量,通过测量植入物稳定价(ISQ)来评估植入稳定性。使用学生的试验,并且在p?<0.05.Resultsthis先进的研究中设定了患者的意义水平。在五名患者中的三个患者中观察到不良事件,其中一个膜的原因和效应关系不能被拒绝在其中一个。在所有五名患者的GBR地区观察到良好的骨形成。在第二种外科手术过程中的ISQ表明所有患者的骨整合。结论p(la / cl)膜的骨骼增加与gbr,使得可以保持增强的骨体积而不会导致任何不可逆的不良事件。但是,需要对人类的进一步调查来证实这种生物材料的安全性。

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