CD1a- and CD83-positive dendritic cells as prognostic markers of metastasis development in early breast cancer patients

摘要

Purpose Dendritic cells (DCs) are the most potent antigen-presenting cells that play a major role in initiating the antitumor immune response in different types of cancer. However, the prognostic significance of the accumulation of these cells in human early breast tumors is not totally clear. The aim of this study is to evaluate the prognostic relevance of CD1a(?+) and CD83(?+) dendritic cells in early breast cancer patients. Methods We conducted immunohistochemical assays to determine the number of stromal CD1a(?+) and CD83(?+) DCs in primary tumors from early invasive ductal breast cancer patients, and analyzed their association with clinico-pathological characteristics. Results Patients with high CD1a(?+) DC number had lower risk of bone metastatic occurrence, as well as, longer disease-free survival (DFS), bone metastasis-free survival (BMFS) and overall survival (OS). Moreover, CD1a(?+) DC number was an independent prognostic factor for BMFS and OS. In contrast, we found that patients with high number of CD83(?+) DCs had lower risk of mix (bone and visceral)-metastatic occurrence. Likewise, these patients presented better prognosis with longer DFS, mix-MFS and OS. Furthermore, CD83(?+) DC number was an independent prognostic factor for DFS and OS. Conclusion The quantification of the stromal infiltration of DCs expressing CD1a or CD83 in early invasive breast cancer patients serves to indicate the prognostic risk of developing metastasis in a specific site.