Inductively coupled, mm-sized, single channel optical neuro-stimulator with intensity enhancer

摘要

We introduce a single channel neuro-stimulator consisting of a reflector-coupled microscale light emitting diode (LED) with an integrated mm-sized wireless receiver (Rx) coil for free-floating, battery-free, untethered optogenetics neuromodulation. The system utilizes a two-coil inductive link to deliver instantaneous power at a low operating frequency (<100MHz) for continuous optical stimulation with minimized invasiveness and tissue exposure to electromagnetic radiation. Coupling a microscale reflector to the LED provides significant light intensity enhancement compared to a bare LED. Our activated stimulators have an operational temperature increase of <1C, well below the safety limit of biomedical implants. In vivo experiment and histological analysis verify the efficacy of wireless optical stimulation in the primary visual cortex of rats, using c-Fos biomarker as a reporter of light-evoked neuronal activity.