HEPATOPROTECTIVE ACTIVITY AND OXIDATIVE STRESS OF THE AQUEOUS EXTRACT OF SEED FROM PINTO BEAN (PHASEOLUS VULGARIS L.) IN STREPTOZOTOCIN INDUCED ALBINO WISTAR RATS

摘要

The aim of the study was to evaluate the anti-diabetic and antioxidant effects of aqueous extract of Phaseolus vulgaris L. seeds in normal and streptozotocin (STZ) induced diabetic rats. Female Albino Wistar rats were divided into 6 groups of 6 rats; each was assigned into diabetic and non-diabetic groups. Diabetes was induced in rats by single intraperitoneal administration of STZ (55 mg/kg body weight). Phaseolus vulgaris L. extract at the doses of 100, 200, and 300 mg/kg body weight and glibenclamide (600 μg/kg b.w.) by intragastric tubation orally administered to both diabetic animals for a period of 30 days. After completion of experimental length, blood serum, liver, and exocrine gland were used for evaluating organic chemistry. Oral administration of Phaseolus vulgaris L. seeds significantly reduced elevated serum glucose, renal, liver function levels and significantly increased serum insulin and body weight as well as improved lipid profile due to diabetes.