Diagnostic significance of circulating miRNAs in Kawasaki disease in China

摘要

Kawasaki disease(KD) isan unknown cause ofself-limited febrile vasculitis, whichmainly affectschildren under 5 years old. [1] KDis the mostcommon cause ofacquired heart diseasein children inmany countries. [2–4] The majoretiology ofKDis unknown. Timely initialtreatment with intravenous immunoglobulin reduced theincidence ofcoronary artery lesions from25%to less than 5%. [5] Delayed diagnosis isassociated with increased coronary artery lesions. [6] In clinical practice, the diagnosis ofKDis mainly based on the AmericanHeart Association [1] or Japanese Cardiology Society Joint WorkingGroup criteria [7]; bothmadeaccording to theclinicalmanifestationsand laboratory tests. Laboratory tests, such as C reactive protein,erythrocytesedimentation rate,and nitrogen-terminalB-type natriuretic peptide(NT-proBNP) havealthough been proved to be important in the diagnosis ofKD, but none ofthemcan accurately diagnose KD. [8,9] Thereis stillalack ofspecificlaboratory indicators for the diagnosis ofKD. Therefore, the search for newand reliablecirculating biomarkers is of greatsignificancefor theearly diagnosis ofKD.