Diffuse cerebral microbleeds in a young adult with Down syndrome

摘要

A 25-year-old male with Down syndrome (DS) [46, XY, der (13;14), 21] underwent brain magnetic resonance imaging (MRI) due to drop attacks. He had mental retardation from childhood (IQ 50) but no subsequent cognitive decline. Consciousness was preserved during each attack and he could walk again 5 minutes later. Brain MRI showed numerous tiny microbleeds in the lobar area (n = 349), infratentorial area (n = 59), and deep regions (n = 28) without superficial hemosiderosis or white-matter lesions (Fig. 1), which would be related to cerebral amyloid angiopathy (CAA).