The use of an oxidative stress scoring system in prognostic prediction for kidney renal clear cell carcinoma

摘要

Oxidative stress induced by reactive oxygen species (ROS) production plays a key role in tumor initiation and progression [1, 2]. Emerging evidence has shown that oxidative stress-related genes could be used as biomarkers for predicting the progression and prognosis of malignant tumors [3]. Our previous study showed that the expression and genotypes of oxidative stress-related genes could be used for predicting the chemosensitivity and clinical outcomes of biliary tract cancer patients [4]. However, the associations between oxidative stress-related genes and kidney renal clear cell carcinoma (KIRC) remain undefined. In this study, we characterized oxidative stress-related genes’ expression in KIRC by systematically analyzing data from 8 independent KIRC databases, namely 4 from the Gene Expression Omnibus (GEO; n = 130, https://www.ncbi.nlm.nih.gov/geo), 1 from The Cancer Genome Atlas (TCGA; n = 535, http://gdac. broadinstitute.org), and 3 from our KIRC verification cohorts (cohort 1 from Ruijin hospital, n = 48; cohort 2 from OutdoBiotech, n = 150; cohort 3 from Shanghai Ninth People’s hospital, n = 306; Supplementary Materials and Methods; Supplementary Table S1). Then, we developed an individualized oxidative stress-related scoring system for predicting the prognosis of KIRC patients.