Serum cystatin C or cystatin C-based glomerular filtration rate may be a better choice in estimating renal function in women with preeclampsia

摘要

Preeclampsia, a progressivepregnancy disorder involving multi- ple organ systems, is defined as new onset hypertension (systolic blood pressure sustained at ? 140 mm Hg or diastolic blood pres- sure at ? 90 mm Hg, or both) with proteinuria or end organ dysfunction after 20 gestational weeks [1]. Preeclampsia is still a biggest challenge in modern obstetrics, especially when women are diagnosed late in the disease pathway with no medical history or when women have pre-existing hypertension and renal disease at the beginning of pregnancy [2e5], because preeclampsia itself is associated with both maternal and perinatal morbidity and mortal- ity, and the when women were accompanied with the latter two conditions, worse pregnancy outcome may be further increased apparently [2e5].