The real-life heart failure patient: importance of guideline-directed medical therapy

摘要

In the past decade the treatment of patients with heart failure with reduced ejection fraction has quickly gained momentum. Numerous randomised controlled trials (RCTs) have proved the benefit of angiotensin receptor-neprilysin inhibitors (ARNIs) and sodium-glucose transport protein 2 inhibitors (SGLT2i) in addition to the current ‘guideline-directed medical therapy’ (GDMT) [1–3]. The novel European Society of Cardiology (ESC) guideline on heart failure (HF) that will be published this year will undoubtedly recommend a substantial change in GDMT, presumably in accordance with the previously published ESC position papers and the American College of Cardiology consensus document [4, 5]. Until then, however, we will have to wait to learn what the exact role of SGLT2i and ARNIs in this new therapeutic algorithm will be.