Multi-scale Order Recurrence Plot based deterministic analysis on Heart Rate Variability in Congestive Heart Failure Assessment

摘要

Congestive heart failure (CHF) is a cardiovascular disease associated with the abnormal autonomic nervous system (ANS). Heart rate variability analysis (HRV) is the main method for the quantitative evaluation of autonomic nervous function. Common analytical methods of HRV include time domain, frequency domain, and nonlinear methods. However, these methods generally ignore the short-term volatility of heart rate and autonomic ganglion law. Therefore, this study proposes a new parameter to analyze heart rate variability-determination of a multi-scale order recurrence plot (MSORP_DET). This method can analyze the HRV in patients with heart failure on multiple time scales. This study analyzed the R-R interval in 24-hour HRV data from 98 samples (54 normal subjects and 44 patients with CHF). The results showed that MSORP_DET could significantly distinguish CHF patients from normal subjects (p<0.001). Moreover, the accuracy rate of screening patients with CHF reached the maximum of 81.6% by using the combination of low frequency/high frequency (LF/HF) and MSORP_DET, compared with 78.6% when using LF/HF alone. Therefore, MSORP_DET can be used as a new index to screen patients with CHF and reveal that the rhythm of ANS in patients with heart failure is more complex than that in normal people.